AUTHOR=Rogina Blanka , Helfand Stephen L.

TITLE=Indy Mutations and Drosophila Longevity

JOURNAL=Frontiers in Genetics

VOLUME=4

YEAR=2013

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2013.00047

DOI=10.3389/fgene.2013.00047

ISSN=1664-8021

ABSTRACT=<p>Decreased expression of the fly and worm <italic>Indy</italic> genes extends longevity. The fly <italic>Indy</italic> gene and its mammalian homolog are transporters of Krebs cycle intermediates, with the highest rate of uptake for citrate. Cytosolic citrate has a role in energy regulation by affecting fatty acid synthesis and glycolysis. Fly, worm, and mice Indy gene homologs are predominantly expressed in places important for intermediary metabolism. Consequently, decreased expression of <italic>Indy</italic> in fly and worm, and the removal of <italic>mIndy</italic> in mice exhibit changes associated with calorie restriction, such as decreased levels of lipids, changes in carbohydrate metabolism and increased mitochondrial biogenesis. Here we report that several <italic>Indy</italic> alleles in a diverse array of genetic backgrounds confer increased longevity.</p>