AUTHOR=Spratt Spencer J.

TITLE=A computation using mutually exclusive processing is sufficient to identify specific Hedgehog signaling components

JOURNAL=Frontiers in Genetics

VOLUME=4

YEAR=2013

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2013.00284

DOI=10.3389/fgene.2013.00284

ISSN=1664-8021

ABSTRACT=<p>A system of more than one part can be deciphered by observing differences between the parts. A simple way to do this is by recording something absolute displaying a trait in one part and not in another: in other words, mutually exclusive computation. Conditional directed expression <italic>in vivo</italic> offers processing in more than one part of the system giving increased computation power for biological systems analysis. Here, I report the consideration of these aspects in the development of an <italic>in vivo</italic> screening assay that appears sufficient to identify components specific to a system.</p>