AUTHOR=Yeger-Lotem Esti , Sharan Roded TITLE=Human protein interaction networks across tissues and diseases JOURNAL=Frontiers in Genetics VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2015.00257 DOI=10.3389/fgene.2015.00257 ISSN=1664-8021 ABSTRACT=

Protein interaction networks are an important framework for studying protein function, cellular processes, and genotype-to-phenotype relationships. While our view of the human interaction network is constantly expanding, less is known about networks that form in biologically important contexts such as within distinct tissues or in disease conditions. Here we review efforts to characterize these networks and to harness them to gain insights into the molecular mechanisms underlying human disease.