AUTHOR=Müller Sören , Diaz Aaron TITLE=Single-Cell mRNA Sequencing in Cancer Research: Integrating the Genomic Fingerprint JOURNAL=Frontiers in Genetics VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2017.00073 DOI=10.3389/fgene.2017.00073 ISSN=1664-8021 ABSTRACT=
Critical cancer mutations are often regional and mosaic, confounding the efficacy of targeted therapeutics. Single cell mRNA sequencing (scRNA-seq) has enabled unprecedented studies of intra-tumor heterogeneity and its role in cancer progression, metastasis, and treatment resistance. When coupled with DNA sequencing, scRNA-seq allows one to infer the