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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2018.00572

Recent trends in system-scale integrative approaches for discovering protective antigens against mycobacterial pathogens

  • 1Central University of Himachal Pradesh, India
  • 2Babasaheb Bhimrao Ambedkar University, India

Mycobacterial infections are one of the deadliest infectious diseases still posing a major health burden worldwide. The battle against these pathogens needs to focus on novel approaches and key interventions. In the recent times, availability of genome scale data has revolutionized the fields of computational biology and immunoproteomics. Here, we summarize the cutting-edge ‘omics’ technologies and innovative system scale strategies exploited to mine the available data. These may be targeted using high-throughput technologies to expedite the identification of novel antigenic candidates for the rational next generation vaccines and serodiagnostic development against mycobacterial pathogens for which traditional methods have been failing.

Keywords: Mycobacterium, Vaccine, Diagnostic Markers, Reverse vaccinology (RV), Antigen discovery

Received: 26 Sep 2018; Accepted: 06 Nov 2018.

Edited by:

Alfredo Pulvirenti, Università degli Studi di Catania, Italy

Reviewed by:

Marco Ragusa, Università degli Studi di Catania, Italy
Sandeep K. Dhanda, La Jolla Institute for Allergy and Immunology (LJI), United States  

Copyright: © 2018 Rana, Thakur, KUMAR and Akhter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Yusuf Akhter, Babasaheb Bhimrao Ambedkar University, Lucknow, India, yusuf@daad-alumni.de