Impact Factor 4.151
2017 JCR, Clarivate Analytics 2018

Frontiers journals are at the top of citation and impact metrics

Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2019.00153

microRNAs in Alzheimer’s disease

 Mengli Wang1, Lixia Qin2 and  Beisha Tang2, 3, 4*
  • 1Xiangya School of Medicine, Central South University, China
  • 2Department of Neurology, Xiangya Hospital, Central South University, China
  • 3Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, China
  • 4National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China

Alzheimer’s Disease (AD) is a progressive and devastating neurodegenerative disorder. It is the leading cause of dementia in the world’s rapidly growing aging population. The characteristics of AD are memory loss and cognitive impairment, meaning patients cannot carry out their daily activities independently. The increase of AD cases poses heavy burdens on families, society and the economy. Despite frequent efforts being made to research the etiology of AD, the causes of AD remain unknown, and no curative treatments are available yet. The pathological hallmarks of AD are amyloid plaques and neurofibrillary tangles in the brain; microRNAs are endogenous ~22 nucleotides non-coding RNAs that could regulate gene expression at a post-transcriptional level by transcript degradation or translation repression. microRNAs are involved in many biological processes and diseases, particularly multifactorial diseases, providing an excellent tool with which to research the mechanisms of these diseases. AD is a multifactorial disorder, and accumulating evidence shows that microRNAs play a critical role in the pathogenesis of AD. In this review, we will highlight the effect of microRNAs in different pathological processes throughout AD progression.

Keywords: Alzheimer’s disease (AD), microRNAs (miRNA, Pathological process, amyloid plaques, Neurofibrillary Tangles

Received: 03 Nov 2018; Accepted: 13 Feb 2019.

Edited by:

Naoyuki Kataoka, University of Tokyo, Japan

Reviewed by:

Walter J. Lukiw, LSU Health Sciences Center New Orleans, United States
Davide De Pietri Tonelli, Istituto Italiano di Tecnologia, Italy  

Copyright: © 2019 Wang, Qin and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Beisha Tang, Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008, Hunan Province, China, bstang7398@163.com