AUTHOR=Wang Jianjun , Qi Jianfeng , Hou Xianzeng 

TITLE=Systematically Dissecting the Function of RNA-Binding Proteins During Glioma Progression

JOURNAL=Frontiers in Genetics

VOLUME=Volume 10 - 2019

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2019.01394

DOI=10.3389/fgene.2019.01394

ISSN=1664-8021

ABSTRACT=RNA binding proteins (RBPs) play important roles in regulating gene expression and dysregulation of RBPs have been observed in various types of cancer. However, the role of RBPs during glioma progression, and particular in Chinese patients, is only starting to be unveiled. Here, we systematically analyzed the genetic mutation, gene expression patterns of 2949 RBPs during glioma progression. Our comprehensive study reveals number of highly mutated genes (such as ATRX, TTN and SETD2) and differentially expressed genes (such as KIF4A, TTK and CEP55). Combined the expression of RBPs and genes, we constructed the regulatory network in glioma and revealed the functional links between RBPs and cancer-related genes. Moreover, we revealed the prognosis spectrum of RBPs during glioma progression. Several RBPs, such as SNRPN and IGF2BP3, were significantly associated with the survival of patients in all grades. Taken together, our analyses provided a valuable of RBP resource during glioma progression, and revealed several candidates that potentially contribute to development of therapeutic targets for glioma.