AUTHOR=Christensen Kurt D. , Bell Megan , Zawatsky Carrie L. B. , Galbraith Lauren N. , Green Robert C. , Hutchinson Allison M. , Jamal Leila , LeBlanc Jessica L. , Leonhard Jennifer R. , Moore Michelle , Mullineaux Lisa , Petry Natasha , Platt Dylan M. , Shaaban Sherin , Schultz April , Tucker Bethany D. , Van Heukelom Joel , Wheeler Elizabeth , Zoltick Emilie S. , Hajek Catherine , on behalf of the Imagenetics Metrics Team , Jordan Baye , Megan Bell , Kristen Deberg , Benjamin Forred , Colette Free , Catherine Hajek , Joel Van Heukelom , Ashley Hopp , Allison Hutchinson , Ryne Lees , Jennifer Leonhard , Amanda Massmann , Michelle Moore , Amelia Mroch , Natasha Petry , Dylan Platt , Erin Royer , April Schultz , Murat Sincan , Bethany Tucker , Elizabeth Wheeler , Kurt Christensen , Lauren Galbraith , Jessica LeBlanc , Ryan Walsh , Emilie Zoltick , Robert Green , Charlene Preys , Carrie Zawatsky , Lisa Mullineaux , Leila Jamal TITLE=Precision Population Medicine in Primary Care: The Sanford Chip Experience JOURNAL=Frontiers in Genetics VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.626845 DOI=10.3389/fgene.2021.626845 ISSN=1664-8021 ABSTRACT=

Genetic testing has the potential to revolutionize primary care, but few health systems have developed the infrastructure to support precision population medicine applications or attempted to evaluate its impact on patient and provider outcomes. In 2018, Sanford Health, the nation’s largest rural nonprofit health care system, began offering genetic testing to its primary care patients. To date, more than 11,000 patients have participated in the Sanford Chip Program, over 90% of whom have been identified with at least one informative pharmacogenomic variant, and about 1.5% of whom have been identified with a medically actionable predisposition for disease. This manuscript describes the rationale for offering the Sanford Chip, the programs and infrastructure implemented to support it, and evolving plans for research to evaluate its real-world impact.