AUTHOR=Dilek Nahzli , Vuillefroy de Silly Romain , Blancho Gilles , Vanhove Bernard 

TITLE=Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance

JOURNAL=Frontiers in Immunology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00208

DOI=10.3389/fimmu.2012.00208

ISSN=1664-3224

ABSTRACT=<p>Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature hematopoietic precursors known to suppress immune responses in infection, chronic inflammation, cancer, and autoimmunity. In this paper, we review recent findings detailing their mode of action and discuss recent reports that suggest that MDSC are also expanded during transplantation and that modulation of MDSC can participate in preventing graft rejection as well as graft-versus-host disease.</p>