AUTHOR=Euler Zelda , Schuitemaker Hanneke 

TITLE=Cross-reactive broadly neutralizing antibodies: timing is everything

JOURNAL=Frontiers in Immunology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00215

DOI=10.3389/fimmu.2012.00215

ISSN=1664-3224

ABSTRACT=<p>The recent surge of research into new broadly neutralizing antibodies in HIV-1 infection has recharged the field of HIV-1 vaccinology. In this review we discuss the currently known broadly neutralizing antibodies and focus on factors that may shape these antibodies in natural infection. We further discuss the role of these antibodies in the clinical course of the infection and consider immunological obstacles in inducing broadly neutralizing antibodies with a vaccine.</p>