AUTHOR=Euler Zelda , Schuitemaker Hanneke TITLE=Cross-reactive broadly neutralizing antibodies: timing is everything JOURNAL=Frontiers in Immunology VOLUME=3 YEAR=2012 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00215 DOI=10.3389/fimmu.2012.00215 ISSN=1664-3224 ABSTRACT=

The recent surge of research into new broadly neutralizing antibodies in HIV-1 infection has recharged the field of HIV-1 vaccinology. In this review we discuss the currently known broadly neutralizing antibodies and focus on factors that may shape these antibodies in natural infection. We further discuss the role of these antibodies in the clinical course of the infection and consider immunological obstacles in inducing broadly neutralizing antibodies with a vaccine.