%A Valitutti,Salvatore %D 2012 %J Frontiers in Immunology %C %F %G English %K T cell antigen receptor,TCR serial engagement,T lymphocyte activation,Signal Transduction,Immunological Synapse %Q %R 10.3389/fimmu.2012.00272 %W %L %M %P %7 %8 2012-August-28 %9 Review %+ Dr Salvatore Valitutti,INSERM,INSERM UMR 1043,INSERM U1043 CHU Purpan,BP 3028 31024 , Toulouse Cedex 3France,Toulouse,31024,France,salvatore.valitutti@inserm.fr %+ Dr Salvatore Valitutti,Université Toulouse III Paul-Sabatier,Toulouse,France,salvatore.valitutti@inserm.fr %+ Dr Salvatore Valitutti,Laboratoire d’Excellence Toulouse Cancer-TOUCAN,Toulouse,France,salvatore.valitutti@inserm.fr %# %! Serial TCR engagement %* %< %T The Serial Engagement Model 17 Years After: From TCR Triggering to Immunotherapy %U https://www.frontiersin.org/articles/10.3389/fimmu.2012.00272 %V 3 %0 JOURNAL ARTICLE %@ 1664-3224 %X More than 15 years ago the serial engagement model was proposed as an attempt to solve the low affinity/high sensitivity paradox of TCR antigen recognition. Since then, the model has undergone ups and downs marked by the technical and conceptual advancements made in the field of T lymphocyte activation. Here, I describe the development of the model and survey recent literature providing evidence either for or against the idea that serial TCR/pMHC engagement might contribute to T lymphocyte activation. I also discuss how the concept of serial TCR engagement might be useful in the design of immunotherapeutic approaches aimed at potentiating T lymphocyte responses in vivo.