AUTHOR=Barao Isabel 

TITLE=The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses

JOURNAL=Frontiers in Immunology

VOLUME=3

YEAR=2013

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00402

DOI=10.3389/fimmu.2012.00402

ISSN=1664-3224

ABSTRACT=<p>Interactions between several tumor necrosis factor (TNF)-TNF receptor (TNFR) superfamily members that are expressed by T cells and natural killer (NK) cells and various other cell types modulate immune responses. This review summarizes the current understanding of how the TNF ligand-TNFR interactions 4-1BBL with 4-1BB, and GITRL with glucocorticoid-induced TNFR-related (GITR) regulate NK cell mediated antitumor responses and discuss its therapeutic implications.</p>