@ARTICLE{10.3389/fimmu.2014.00092, AUTHOR={Avalos, Ana and Ploegh, Hidde}, TITLE={Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells}, JOURNAL={Frontiers in Immunology}, VOLUME={5}, YEAR={2014}, URL={https://www.frontiersin.org/articles/10.3389/fimmu.2014.00092}, DOI={10.3389/fimmu.2014.00092}, ISSN={1664-3224}, ABSTRACT={B cells are efficient antigen-presenting cells (APCs), relying on antigen uptake through the B cell receptor (BCR). The mechanism of antigen recognition remains a topic of debate; while the prevalent view holds that antigens need to be multivalent for BCR activation, monovalent antigens can also initiate B cell responses. In this review, we describe the steps required for antigen uptake, processing, and loading of peptides onto MHC Class II compartments in B cells for efficient presentation to CD4 T cells, with a special focus in the initial steps of BCR recognition of antigen.} }