AUTHOR=Bettelheim Karl A. , Goldwater Paul N. 

TITLE=Escherichia coli and Sudden Infant Death Syndrome

JOURNAL=Frontiers in Immunology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00343

DOI=10.3389/fimmu.2015.00343

ISSN=1664-3224

ABSTRACT=<p>This review examines the association of strains of <italic>Escherichia coli</italic> with sudden infant death syndrome (SIDS) and the possible role these bacteria play in this enigmatic condition. The review addresses evidence for <italic>E. coli</italic> in SIDS infants, potential sources of <italic>E. coli</italic> in the environment, colonization by commensal and pathogenic strains, the variety of currently accepted pathotypes, and how these pathotypes could compromise intestinal integrity and induce inflammation. Both intestinal and extraintestinal pathotypes are compared in relation to the apparent liability in which virulence traits can be gained or lost by strains of <italic>E. coli</italic>. The way in which <italic>E. coli</italic> infections fit with current views on infant sleeping position and other SIDS risk factors is highlighted.</p>