AUTHOR=Wong-Baeza Carlos , Reséndiz-Mora Albany , Donis-Maturano Luis , Wong-Baeza Isabel , Zárate-Neira Luz , Yam-Puc Juan Carlos , Calderón-Amador Juana , Medina Yolanda , Wong Carlos , Baeza Isabel , Flores-Romo Leopoldo TITLE=Anti-Lipid IgG Antibodies Are Produced via Germinal Centers in a Murine Model Resembling Human Lupus JOURNAL=Frontiers in Immunology VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2016.00396 DOI=10.3389/fimmu.2016.00396 ISSN=1664-3224 ABSTRACT=
Anti-lipid IgG antibodies are produced in some mycobacterial infections and in certain autoimmune diseases [such as anti-phospholipid syndrome, systemic lupus erythematosus (SLE)]. However, few studies have addressed the B cell responses underlying the production of these immunoglobulins. Anti-lipid IgG antibodies are consistently found in a murine model resembling human lupus induced by chlorpromazine-stabilized non-bilayer phospholipid arrangements (NPA). NPA are transitory lipid associations found in the membranes of most cells; when NPA are stabilized they can become immunogenic and induce specific IgG antibodies, which appear to be involved in the development of the mouse model of lupus. Of note, anti-NPA antibodies are also detected in patients with SLE and leprosy. We used this model of lupus to investigate