AUTHOR=Binder Sebastian C. , Meyer-Hermann Michael 

TITLE=Implications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division

JOURNAL=Frontiers in Immunology

VOLUME=Volume 7 - 2016

YEAR=2016

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2016.00593

DOI=10.3389/fimmu.2016.00593

ISSN=1664-3224

ABSTRACT=Intravital imaging of antibody optimization in germinal centre (GC) reactions has
set a new dimension in the understanding of the humoral immune response during
the last decade. The inclusion of spatio-temporal cellular dynamics in
the research on GCs required analysis with agent-based mathematical models.
Here, we integrate the available intravital imaging data from various research
groups and incorporate these into a quantitative mathematical model of
GC reactions and antibody affinity maturation. Interestingly, the integration
of data concerning the spatial organisation of GCs and B cell motility allows to draw
conclusions on the strength of the selection pressure and the control
of B cell division by T follicular helper cells.