AUTHOR=Huang Feng , Chen Maogen , Chen Weiqian , Gu Jian , Yuan Jia , Xue Yaoqiu , Dang Junlong , Su Wenru , Wang Julie , Zadeh Homayoun H. , He Xiaoshun , Rong Limin , Olsen Nancy , Zheng Song Guo TITLE=Human Gingiva-Derived Mesenchymal Stem Cells Inhibit Xeno-Graft-versus-Host Disease via CD39–CD73–Adenosine and IDO Signals JOURNAL=Frontiers in Immunology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00068 DOI=10.3389/fimmu.2017.00068 ISSN=1664-3224 ABSTRACT=
Mesenchymal stem cells have the capacity to maintain immune homeostasis and prevent autoimmunity. We recently reported that human-derived gingival mesenchymal stem cells (GMSCs) have strong capacity to suppress immune responses and T cell-mediated collagen-induced arthritis in animals. However, it is unclear whether these cells can suppress human T cell-mediated diseases. Here, we used a xenogenic GVHD model in the NOD/SCID mouse, which is a useful preclinical construct for evaluating the therapeutic and translational potential of this approach for applications in human disease. We found that GMSCs potently suppressed the proliferation of PBMC and T cells