@ARTICLE{10.3389/fimmu.2017.00454, AUTHOR={Laurent, Paôline and Jolivel, Valérie and Manicki, Pauline and Chiu, Lynn and Contin-Bordes, Cécile and Truchetet, Marie-Elise and Pradeu, Thomas}, TITLE={Immune-Mediated Repair: A Matter of Plasticity}, JOURNAL={Frontiers in Immunology}, VOLUME={8}, YEAR={2017}, URL={https://www.frontiersin.org/articles/10.3389/fimmu.2017.00454}, DOI={10.3389/fimmu.2017.00454}, ISSN={1664-3224}, ABSTRACT={Though the immune system is generally defined as a system of defense, it is increasingly recognized that the immune system also plays a crucial role in tissue repair and its potential dysregulations. In this review, we explore how distinct immune cell types are involved in tissue repair and how they interact in a process that is tightly regulated both spatially and temporally. We insist on the concept of immune cell plasticity which, in recent years, has proved fundamental for the success/understanding of the repair process. Overall, the perspective presented here suggests that the immune system plays a central role in the physiological robustness of the organism, and that cell plasticity contributes to the realization of this robustness.} }