%A Yamamoto,Yoshinari
%A Sugimura,Ryu
%A Watanabe,Takafumi
%A Shigemori,Suguru
%A Okajima,Takuma
%A Nigar,Shireen
%A Namai,Fu
%A Sato,Takashi
%A Ogita,Tasuku
%A Shimosato,Takeshi
%D 2017
%J Frontiers in Immunology
%C
%F
%G English
%K Class A CpG ODN,Sepsis,LPS,PAF,PAF-AH,DIC
%Q
%R 10.3389/fimmu.2017.01049
%W
%L
%M
%P
%7
%8 2017-August-30
%9 Original Research
%+ Takeshi Shimosato,Department of Interdisciplinary Genome Sciences and Cell Metabolism, Institute for Biomedical Sciences, Shinshu University,Japan,shimot@shinshu-u.ac.jp
%+ Takeshi Shimosato,Department of Supramolecular Complexes, Research Center for Fungal and Microbial Dynamism, Shinshu University,Japan,shimot@shinshu-u.ac.jp
%#
%! Class A CpG ODN rescues mice from sepsis
%*
%<
%T Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase
%U https://www.frontiersin.org/articles/10.3389/fimmu.2017.01049
%V 8
%0 JOURNAL ARTICLE
%@ 1664-3224
%X Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock. As a mechanism of pathogenesis, platelet-activating factor (PAF) induces excessive inflammatory responses and blood clotting. In this study, we demonstrate that a Class A CpG oligodeoxynucleotide (CpG-A1585) strongly induced PAF acetylhydrolase, which generates lyso-PAF. CpG-A1585 rescued mice from acute lethal shock and decreased fibrin deposition, a hallmark of PAF-induced disseminated intravascular coagulation. Furthermore, CpG-A1585 improved endotoxin shock induced by lipopolysaccharide, which comprises the cell wall of Gram-negative bacteria and inhibits inflammatory responses induced by cytokines such as interleukin-6 and tumor necrosis factor-α. These results suggest that CpG-A1585 is a potential therapeutic target to prevent sepsis-related induction of PAF.