%A Yamamoto,Yoshinari %A Sugimura,Ryu %A Watanabe,Takafumi %A Shigemori,Suguru %A Okajima,Takuma %A Nigar,Shireen %A Namai,Fu %A Sato,Takashi %A Ogita,Tasuku %A Shimosato,Takeshi %D 2017 %J Frontiers in Immunology %C %F %G English %K Class A CpG ODN,Sepsis,LPS,PAF,PAF-AH,DIC %Q %R 10.3389/fimmu.2017.01049 %W %L %M %P %7 %8 2017-August-30 %9 Original Research %+ Takeshi Shimosato,Department of Interdisciplinary Genome Sciences and Cell Metabolism, Institute for Biomedical Sciences, Shinshu University,Japan,shimot@shinshu-u.ac.jp %+ Takeshi Shimosato,Department of Supramolecular Complexes, Research Center for Fungal and Microbial Dynamism, Shinshu University,Japan,shimot@shinshu-u.ac.jp %# %! Class A CpG ODN rescues mice from sepsis %* %< %T Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase %U https://www.frontiersin.org/articles/10.3389/fimmu.2017.01049 %V 8 %0 JOURNAL ARTICLE %@ 1664-3224 %X Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock. As a mechanism of pathogenesis, platelet-activating factor (PAF) induces excessive inflammatory responses and blood clotting. In this study, we demonstrate that a Class A CpG oligodeoxynucleotide (CpG-A1585) strongly induced PAF acetylhydrolase, which generates lyso-PAF. CpG-A1585 rescued mice from acute lethal shock and decreased fibrin deposition, a hallmark of PAF-induced disseminated intravascular coagulation. Furthermore, CpG-A1585 improved endotoxin shock induced by lipopolysaccharide, which comprises the cell wall of Gram-negative bacteria and inhibits inflammatory responses induced by cytokines such as interleukin-6 and tumor necrosis factor-α. These results suggest that CpG-A1585 is a potential therapeutic target to prevent sepsis-related induction of PAF.