TY - JOUR
AU - Yamamoto, Yoshinari
AU - Sugimura, Ryu
AU - Watanabe, Takafumi
AU - Shigemori, Suguru
AU - Okajima, Takuma
AU - Nigar, Shireen
AU - Namai, Fu
AU - Sato, Takashi
AU - Ogita, Tasuku
AU - Shimosato, Takeshi
PY - 2017
M3 - Original Research
TI - Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase
JO - Frontiers in Immunology
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2017.01049
VL - 8
SN - 1664-3224
N2 - Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock. As a mechanism of pathogenesis, platelet-activating factor (PAF) induces excessive inflammatory responses and blood clotting. In this study, we demonstrate that a Class A CpG oligodeoxynucleotide (CpG-A1585) strongly induced PAF acetylhydrolase, which generates lyso-PAF. CpG-A1585 rescued mice from acute lethal shock and decreased fibrin deposition, a hallmark of PAF-induced disseminated intravascular coagulation. Furthermore, CpG-A1585 improved endotoxin shock induced by lipopolysaccharide, which comprises the cell wall of Gram-negative bacteria and inhibits inflammatory responses induced by cytokines such as interleukin-6 and tumor necrosis factor-α. These results suggest that CpG-A1585 is a potential therapeutic target to prevent sepsis-related induction of PAF.
ER -