TY - JOUR AU - Yamamoto, Yoshinari AU - Sugimura, Ryu AU - Watanabe, Takafumi AU - Shigemori, Suguru AU - Okajima, Takuma AU - Nigar, Shireen AU - Namai, Fu AU - Sato, Takashi AU - Ogita, Tasuku AU - Shimosato, Takeshi PY - 2017 M3 - Original Research TI - Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase JO - Frontiers in Immunology UR - https://www.frontiersin.org/articles/10.3389/fimmu.2017.01049 VL - 8 SN - 1664-3224 N2 - Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock. As a mechanism of pathogenesis, platelet-activating factor (PAF) induces excessive inflammatory responses and blood clotting. In this study, we demonstrate that a Class A CpG oligodeoxynucleotide (CpG-A1585) strongly induced PAF acetylhydrolase, which generates lyso-PAF. CpG-A1585 rescued mice from acute lethal shock and decreased fibrin deposition, a hallmark of PAF-induced disseminated intravascular coagulation. Furthermore, CpG-A1585 improved endotoxin shock induced by lipopolysaccharide, which comprises the cell wall of Gram-negative bacteria and inhibits inflammatory responses induced by cytokines such as interleukin-6 and tumor necrosis factor-α. These results suggest that CpG-A1585 is a potential therapeutic target to prevent sepsis-related induction of PAF. ER -