AUTHOR=Lecciso Mariangela , Ocadlikova Darina , Sangaletti Sabina , Trabanelli Sara , De Marchi Elena , Orioli Elisa , Pegoraro Anna , Portararo Paola , Jandus Camilla , Bontadini Andrea , Redavid Annarita , Salvestrini Valentina , Romero Pedro , Colombo Mario P. , Di Virgilio Francesco , Cavo Michele , Adinolfi Elena , Curti Antonio TITLE=ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells JOURNAL=Frontiers in Immunology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01918 DOI=10.3389/fimmu.2017.01918 ISSN=1664-3224 ABSTRACT=
Chemotherapy-induced immunogenic cell death can favor dendritic cell (DC) cross-priming of tumor-associated antigens for T cell activation thanks to the release of damage-associated molecular patterns, including ATP. Here, we tested the hypothesis that in acute myeloid leukemia (AML), ATP release, along with its well-known immune stimulatory effect, may also contribute to the generation of an immune suppressive microenvironment. In a cohort of AML patients, undergoing combined daunorubicin and cytarabine chemotherapy, a population of T regulatory cells (Tregs) with suppressive phenotype, expressing the immune checkpoint programmed cell death protein 1 (PD-1), was significantly increased. Moving from these results, initial