%A Hagert,Cecilia %A Sareila,Outi %A Kelkka,Tiina %A Jalkanen,Sirpa %A Holmdahl,Rikard %D 2018 %J Frontiers in Immunology %C %F %G English %K Macrophage mannose receptor (CD206),Rheumatoid arthritis,psoriatic arthritis,Psoriasis,reactive oxygen species (ROS),mannan,mouse models %Q %R 10.3389/fimmu.2018.00114 %W %L %M %P %7 %8 2018-February-06 %9 Original Research %+ Rikard Holmdahl,Medicity Research Laboratory, University of Turku,Finland,rikard.holmdahl@ki.se %+ Rikard Holmdahl,Medical Inflammation Research, Karolinska Institutet,Sweden,rikard.holmdahl@ki.se %# %! The macrophage mannose receptor protects against mouse psoriasis and arthritis %* %< %T The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models %U https://www.frontiersin.org/articles/10.3389/fimmu.2018.00114 %V 9 %0 JOURNAL ARTICLE %@ 1664-3224 %X The injection of mannan into mice can result in the development of psoriasis (Ps) and psoriatic arthritis (PsA), whereas co-injection with antibodies toward collagen type II leads to a chronic rheumatoid-like arthritis. The critical event in all these diseases is mannan-mediated activation of macrophages, causing more severe disease if the macrophages are deficient in neutrophil cytosolic factor 1 (Ncf1), i.e., lack the capacity to make a reactive oxygen species (ROS) burst. In this study, we investigated the role of one of the receptors binding mannan; the macrophage mannose receptor (MR, CD206). MR is a C-type lectin present on myeloid cells and lymphatics. We found that mice deficient in MR expression had more severe mannan-induced Ps, PsA as well as rheumatoid-like arthritis. Interestingly, the MR-mediated protection was partly lost in Ncf1 mutated mice and was associated with an type 2 macrophage expansion. In conclusion, these results show that MR protects against a pathogenic inflammatory macrophage response induced by mannan and is associated with induction of ROS.