AUTHOR=Tang Juan , Lin Guoxin , Langdon Wallace Y. , Tao Lijian , Zhang Jian 

TITLE=Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00123

DOI=10.3389/fimmu.2018.00123

ISSN=1664-3224

ABSTRACT=<p>Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system.</p>