AUTHOR=Deenick Elissa K. , Pelham Simon J. , Kane Alisa , Ma Cindy S. TITLE=Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00168 DOI=10.3389/fimmu.2018.00168 ISSN=1664-3224 ABSTRACT=

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes. As such, it plays a critical role in regulating B cells as well as CD4+ and CD8+ T cells. Patients with clinically significant immunodeficiency and immune dysregulation resulting from loss-of-function or gain-of-function mutations in STAT3 have been described. These individuals provide insight into the critical role of this transcription factor in the regulation of immune responses and the balance between effective immune protection and autoimmunity.