AUTHOR=Samavedam Unni K. , Mitschker Nina , Kasprick Anika , Bieber Katja , Schmidt Enno , Laskay Tamás , Recke Andreas , Goletz S. , Vidarsson Gestur , Schulze Franziska S. , Armbrust Mikko , Schulze Dieckhoff Katharina , Pas Hendri H. , Jonkman Marcel F. , Kalies Kathrin , Zillikens Detlef , Gupta Yask , Ibrahim Saleh M. , Ludwig Ralf J. TITLE=Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00249 DOI=10.3389/fimmu.2018.00249 ISSN=1664-3224 ABSTRACT=
Because of the morbidity and limited therapeutic options of autoimmune diseases, there is a high, and thus far, unmet medical need for development of novel treatments. Pemphigoid diseases, such as epidermolysis bullosa acquisita (EBA), are prototypical autoimmune diseases that are caused by autoantibodies targeting structural proteins of the skin, leading to inflammation, mediated by myeloid cells. To identify novel treatment targets, we performed cutaneous genome-wide mRNA expression profiling in 190 outbred mice after EBA induction. Comparison of genome-wide mRNA expression profiles in diseased and healthy mice, and construction of a co-expression network identified