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Autoantibodies

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Front. Immunol. | doi: 10.3389/fimmu.2018.00386

The role of mast cells in autoimmune bullous dermatoses

  • 1Forschungszentrum Borstel (LG), Germany
  • 2University of Lübeck, Germany

Skin mast cells (MCs), a resident immune cell type with broad regulatory capacity, play an important role in sensing danger signals as well as in the control of the local immune response. It is conceivable to expect that skin MCs regulate autoimmune response and thus are involved in autoimmune diseases in the skin, e.g. autoimmune bullous dermatoses (AIBD). Therefore, exploring the role of MCs in AIBD will improve our understanding of the disease pathogenesis and the search for novel therapeutic targets. Previously, in clinical studies with AIBD, particularly bullous pemphigoid (BP), patients’ samples have demonstrated that MCs are likely involved in the development of the diseases. However, using MC-deficient mice, studies with mouse models of AIBD have obtained inconclusive or even discrepant results. Therefore, it is necessary to clarify the observed discrepancies and to elucidate the role of MCs in AIBD. Here, in this review, we aim to clarify discrepant findings and finally elucidate the role of MCs in AIBD by summarizing and discussing the findings in both clinical and experimental studies.

Keywords: Mast Cells, autoimmune bullous dermatoses, mouse models, Autoantibodies, Pathogenesis

Received: 29 Nov 2017; Accepted: 12 Feb 2018.

Edited by:

Falk Nimmerjahn, University of Erlangen-Nuremberg, Germany

Reviewed by:

Maja Wallberg, University of Cambridge, United Kingdom
Yisong Wan, University of North Carolina at Chapel Hill, United States  

Copyright: © 2018 Yu, Kasprick, Hartmann and Petersen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Frank Petersen, Forschungszentrum Borstel (LG), Borstel, Germany, fpetersen@fz-borstel.de