TY - JOUR AU - Díaz-Muñoz, Manuel D. AU - Turner, Martin PY - 2018 M3 - Review TI - Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System JO - Frontiers in Immunology UR - https://www.frontiersin.org/articles/10.3389/fimmu.2018.01094 VL - 9 SN - 1664-3224 N2 - Fighting external pathogens requires an ever-changing immune system that relies on tight regulation of gene expression. Transcriptional control is the first step to build efficient responses while preventing immunodeficiencies and autoimmunity. Post-transcriptional regulation of RNA editing, location, stability, and translation are the other key steps for final gene expression, and they are all controlled by RNA-binding proteins (RBPs). Nowadays we have a deep understanding of how transcription factors control the immune system but recent evidences suggest that post-transcriptional regulation by RBPs is equally important for both development and activation of immune responses. Here, we review current knowledge about how post-transcriptional control by RBPs shapes our immune system and discuss the perspective of RBPs being the key players of a hidden immune cell epitranscriptome. ER -