%A Wang,Yaxin %A Li,Yajun %A Meng,Xiangwei %A Duan,Xiumei %A Wang,Meilan %A Chen,Wenqing %A Tang,Tongyu %A Li,Yuqin %D 2018 %J Frontiers in Immunology %C %F %G English %K Epstein-Barr virus infection,T-cell lymphoproliferative disease,Clinical features,Endoscopic features,differential diagnosis %Q %R 10.3389/fimmu.2018.02583 %W %L %M %P %7 %8 2018-November-16 %9 Case Report %# %! EBV+T-LPD: A case study %* %< %T Epstein-Barr Virus-Associated T-Cell Lymphoproliferative Disorder Presenting as Chronic Diarrhea and Intestinal Bleeding: A Case Report %U https://www.frontiersin.org/articles/10.3389/fimmu.2018.02583 %V 9 %0 JOURNAL ARTICLE %@ 1664-3224 %X Systemic Epstein-Barr virus-positive T-cell lymphoproliferative childhood disease (EBV+ T-LPD) is extremely rare. Primary acute or chronic active Epstein-Barr virus infection triggers EBV+ T-LPD's onset and the disease involves clonal proliferation of infected T-cells with activated cytotoxic phenotype. The adult-onset EBV+ T-LPD (ASEBV+ T-LPD) is even rarer and needs to be extensively studied. Further, according to literature review, it is a challenge to find patients who are immunocompetent and diagnosed with ASEBV+ T-LPD involving gastrointestinal tract. This case report discusses a previously healthy middle aged woman who presented with unique symptoms mimicking inflammatory bowel disease, and required a total colectomy and terminal ileum rectomy, as reveled by endoscopic examinations, due to severe gastrointestinal bleeding. Post-surgery histopathological findings were confirmatory for the diagnosis of ASEBV+ T-LPD (II: Borderline). This patient died 7 months after the diagnosis.