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Front. Immunol. | doi: 10.3389/fimmu.2018.02674

Protection against invasive infections in children caused by encapsulated bacteria

  • 1University of British Columbia, Canada

The encapsulated bacteria Streptococcus pneumoniae, Neisseria meningitis, Haemophilus influenzae and Streptococcus agalactiae (Group B Streptococcus) have been responsible for the majority of severe infections in children for decades, specifically bacteremia and meningitis. Isolates which cause invasive disease are usually surrounded by a polysaccharide capsule, which is a major virulence factor and the key antigen in protective protein-polysaccharide conjugate vaccines. Protection against these bacteria is largely mediated via polysaccharide-specific antibody and complement, although the contribution of these and other components, and the precise mechanisms, vary between species and include opsonophagocytosis and complement-dependent bacteriolysis. Further studies are required to more precisely elucidate mechanisms of protection against non-type b H. influenzae and Group B Streptococcus.

Keywords: Sepsis, Bacteremia, Meningitis, Haemophilus influenzae, Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus), Streptococcus agalactiae, Group B Streptococcus (GBS)

Received: 23 Jul 2018; Accepted: 30 Oct 2018.

Edited by:

Johannes Trück, Universitäts-Kinderspital Zürich, Switzerland

Reviewed by:

Tobias Tenenbaum, Universitätsmedizin Mannheim (UMM), Germany
Christoph Aebi, University Children’s Hospital Bern, Switzerland  

Copyright: © 2018 Sadarangani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Manish Sadarangani, University of British Columbia, Vancouver, Canada, msadarangani@bcchr.ubc.ca