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Front. Immunol. | doi: 10.3389/fimmu.2018.02987

IL-2 Regulation of Effector and Memory CD8 T cell Differentiation– A balancing act

  • 1Department of Pediatrics, School of Medicine, University of Washington, United States

Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology – signaling through distinct pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum of physiological outcomes such as cell survival, proliferation and effector differentiation. In addition to driving effector differentiation, IL-2 signals are also critical for formation of long-lived CD8 T cell memory. This review discusses a model of rheostatic control of CD8 T cell effector and memory differentiation by IL-2, wherein the timing, duration, dose and source of IL-2 signals are considered in fine-tuning the balance of key transcriptional regulators of cell fate.

Keywords: IL-2, CD8 T cell memory, terminal effectors, autocrine, Transcription Factors, Metabolism

Received: 16 Oct 2018; Accepted: 04 Dec 2018.

Edited by:

Michael Vajdy, EpitoGenesis (United States), United States

Reviewed by:

Kimberly S. Schluns, University of Texas MD Anderson Cancer Center, United States
Carmen Gerlach, Karolinska Institute (KI), Sweden  

Copyright: © 2018 Kalia and Sarkar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Vandana Kalia, School of Medicine, University of Washington, Department of Pediatrics, Seattle, 16802, PA, United States, vkalia@uw.edu
Dr. Surojit Sarkar, School of Medicine, University of Washington, Department of Pediatrics, Seattle, 16802, PA, United States, sarkars@uw.edu