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BCR Signaling and B Cell Activation

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Front. Immunol. | doi: 10.3389/fimmu.2019.00318

B Cell Dysfunction Associated with Aging and Autoimmune Diseases

  • 1Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, China

Impaired humoral responses, as well as an increased propensity for autoimmunity, play an important role in the development of immune system dysfunction associated with aging. Accumulation of a subset of atypical B cells, termed age-associated B cells (ABCs), is one of the key age-related changes in B cell compartments. ABCs are characterized by their distinct phenotypes, gene expression profiles, special survival requirements, variations in B cell receptor repertoires and unique functions. Here, we summarize recent progress in the knowledge base related to the features of ABCs, their potential role in immune senescence, and their relationship with autoimmune diseases.

Keywords: Aging, B cells, Autoimmunity, BCR repertoires, T-bet

Received: 31 Aug 2018; Accepted: 06 Feb 2019.

Edited by:

Tae Jin Kim, Sungkyunkwan University, South Korea

Reviewed by:

Bruce D. Mazer, Research Institute of the McGill University Health Center, Canada
Christopher Sundling, Karolinska Institute (KI), Sweden  

Copyright: © 2019 Ma, Wang and Hao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Yi Hao, Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China, haoyi@hust.edu.cn