%A Peng,Yu %A Liu,Baozhu %A Pei,Shanshan %A Zheng,Dong %A Wang,Zhanhang %A Ji,Teng %A Pan,Suyue %A Shen,Hai-Ying %A Wang,Honghao %D 2019 %J Frontiers in Immunology %C %F %G English %K anti-NMDAR encephalitis,Neuroinflammation,cytokine,NLRP3,modified Rankin Scale (mRS) %Q %R 10.3389/fimmu.2019.00905 %W %L %M %P %7 %8 2019-May-31 %9 Brief Research Report %# %! CSF NLRP3 in Anti-N-menthyl-D-aspartate receptor encephalitis %* %< %T Higher CSF Levels of NLRP3 Inflammasome Is Associated With Poor Prognosis of Anti-N-methyl-D-Aspartate Receptor Encephalitis %U https://www.frontiersin.org/articles/10.3389/fimmu.2019.00905 %V 10 %0 JOURNAL ARTICLE %@ 1664-3224 %X Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is accepted as an autoimmune disorder of the central nervous system (CNS). NLR family pyrin domain containing 3 (NLRP3) inflammasome, a potent innate inflammatory mediator, can activate IL-1β and induce the migration of T helper cell into CNS. However, the possible role of NLRP3 inflammasome in the pathogenesis of anti-NMDAR encephalitis remains unclear. This study aims to determine the levels of NLRP3 and related cytokines (IL-1β, IL-6, and IL-17) in the cerebrospinal fluid (CSF) of anti-NMDAR encephalitis patients and to assess whether NLRP3 influences the clinical outcomes of this disease. Twenty-five patients with anti-NMDAR encephalitis, 12 viral meningoencephalitis patients and 26 controls with non-inflammatory neurological diseases were recruited. CSF NLRP3 inflammasome, IL-1β, IL-6, and IL-17 were measured by enzyme-linked immunosorbent assay. Thirteen out of 25 patients were re-examed for the concentrations of NLRP3 and cytokines 6 months later. Our results showed significant increases of CSF NLRP3 inflammasome, IL-1β, IL-6, and IL-17 in anti-NMDAR encephalitis patients. There were positive correlations between CSF NLRP3 inflammasome and cytokines in anti-NMDAR encephalitis patients. There was also a positive correlation between maximum modified Rankin Scale (mRS) scores and CSF NLRP3 inflammasome in anti-NMDAR encephalitis patients. During follow-up, the decrease of mRS was positively correlated with the decrease of CSF NLRP3 inflammasomes. These results suggested that the level of CSF NLRP3 inflammasome could represent the severity of anti-NMDAR encephalitis and the reduction of CSF NLRP3 inflammasome could act as an indicator for the prognosis of this disease.