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Immunity and Immunopathogenesis to Herpesviruses

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Front. Immunol. | doi: 10.3389/fimmu.2019.01155

Subversion of Immune Response by Human Cytomegalovirus

  • 1Institute of Life Sciences (ILS), India

Human cytomegalovirus (HCMV) is the most common cause of congenital infections and is an important pathogen in immunocompromised individuals. Despite a robust host immune system, HCMV able to replicate, evade host defenses, establish latency for life. A significant portion of HCMV genome dedicated to encode gene products for modulation of host immune response. Growing number of HCMV gene products are being recognized to play role in immune evasion. Information on viral immune evasion mechanisms by which HCMV persists in host will be useful in devising antiviral intervention strategies and development of new vaccines. This minireview provides a brief overview of immune evasion strategy adapted by HCMV by utilizing its gene product in modulation of host immune response.

Keywords: HCMV (human cytomegalovirus), Immune Evasion, Pathogenesis, Superinfection, Vaccine

Received: 28 Nov 2018; Accepted: 07 May 2019.

Edited by:

Richard D. Dix, Georgia State University, United States

Reviewed by:

Sarah Rowland-Jones, Nuffield Department of Medicine, Medical Sciences Division, University of Oxford, United Kingdom
Edward Mocarski, Emory University, United States  

Copyright: © 2019 Patro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. A. Raj Kumar Patro, Institute of Life Sciences (ILS), Bhubaneswar, India, rajkumarpatro@yahoo.com