AUTHOR=Yang Linjiang , Wang Mingshu , Cheng Anchun , Yang Qiao , Wu Ying , Jia Renyong , Liu Mafeng , Zhu Dekang , Chen Shun , Zhang Shaqiu , Zhao Xinxin , Huang Juan , Wang Yin , Xu Zhiwen , Chen Zhengli , Zhu Ling , Luo Qihui , Liu Yunya , Yu Yanling , Zhang Ling , Tian Bin , Pan Leichang , Rehman Mujeeb Ur , Chen Xiaoyue TITLE=Innate Immune Evasion of Alphaherpesvirus Tegument Proteins JOURNAL=Frontiers in Immunology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.02196 DOI=10.3389/fimmu.2019.02196 ISSN=1664-3224 ABSTRACT=

Alphaherpesviruses are a large family of highly successful human and animal DNA viruses that can establish lifelong latent infection in neurons. All alphaherpesviruses have a protein-rich layer called the tegument that, connects the DNA-containing capsid to the envelope. Tegument proteins have a variety of functions, playing roles in viral entry, secondary envelopment, viral capsid nuclear transportation during infection, and immune evasion. Recently, many studies have made substantial breakthroughs in characterizing the innate immune evasion of tegument proteins. A wide range of antiviral tegument protein factors that control incoming infectious pathogens are induced by the type I interferon (IFN) signaling pathway and other innate immune responses. In this review, we discuss the immune evasion of tegument proteins with a focus on herpes simplex virus type I.