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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.02241

Therapeutic potential of ω-3 polyunsaturated fatty acids in Human Autoimmune and Neurological Diseases

 Xinyun Bi1,  Xiaoxi Li2,  Shuai Wang1,  Zongmeng Zhang1, Fanghong Li1* and Allan Z. Zhao1*
  • 1The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, China
  • 2Department of Immunology, Nanjing Medical University, China

The recognition of ω-3 polyunsaturated acids(PUFAs) as essential fatty acids to normal growth and health was realized more than 80 years ago. However, the awareness of the long-term nutritional intake of ω-3 PUFAs in lowering the risk of a variety of chronic human diseases has grown exponentially only since 1980s. Despite the overwhelming epidemiological evidence, many attempts of using fish-oil supplementation to intervene human diseases have generated conflicting and often ambiguous outcomes; null or weak supporting conclusions were derived in the subsequent META analysis. Different dosages as well as the sources of fish-oil may have contributed to the conflicting outcomes of intervention carried out at different clinics. However, over the past decade,mounting evidence derived from genetic mouse models and clinical studies has shed new light on the functions and the underlying mechanisms of ω-3 PUFAs and their metabolites in the prevention and treatment of rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, and neurological diseases. In this review, we have systematically summarized the current understanding of the effects as well as the underlying mechanisms of ω-3 PUFAs on autoimmune diseases.

Keywords: ω-3 polyunsaturated fatty acids, Autoimmune Diseases, Inflammation, Eicosanoids, mTOR – mammalian target of rapamycin

Received: 26 Apr 2019; Accepted: 04 Sep 2019.

Copyright: © 2019 Bi, Li, Wang, Zhang, Li and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Fanghong Li, Guangdong University of Technology, The School of Biomedical and Pharmaceutical Sciences, Guangzhou, 510006, Guangdong Province, China, fli@gdut.edu.cn
Prof. Allan Z. Zhao, Guangdong University of Technology, The School of Biomedical and Pharmaceutical Sciences, Guangzhou, 510006, Guangdong Province, China, azzhao@gdut.edu.cn