@ARTICLE{10.3389/fimmu.2019.02393, AUTHOR={Fucikova, Jitka and Palova-Jelinkova, Lenka and Bartunkova, Jirina and Spisek, Radek}, TITLE={Induction of Tolerance and Immunity by Dendritic Cells: Mechanisms and Clinical Applications}, JOURNAL={Frontiers in Immunology}, VOLUME={10}, YEAR={2019}, URL={https://www.frontiersin.org/articles/10.3389/fimmu.2019.02393}, DOI={10.3389/fimmu.2019.02393}, ISSN={1664-3224}, ABSTRACT={Dendritic cells (DCs) are key regulators of immune responses that operate at the interface between innate and adaptive immunity, and defects in DC functions contribute to the pathogenesis of a variety of disorders. For instance, cancer evolves in the context of limited DC activity, and some autoimmune diseases are initiated by DC-dependent antigen presentation. Thus, correcting aberrant DC functions stands out as a promising therapeutic paradigm for a variety of diseases, as demonstrated by an abundant preclinical and clinical literature accumulating over the past two decades. However, the therapeutic potential of DC-targeting approaches remains to be fully exploited in the clinic. Here, we discuss the unique features of DCs that underlie the high therapeutic potential of DC-targeting strategies and critically analyze the obstacles that have prevented the full realization of this promising paradigm.} }