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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.02532

Biology of IL-36 signaling and its role in systemic inflammatory diseases

Zhi-Chao Yuan1,  Wang-Dong Xu2, Lu Fu3, Xiao-Yan Liu4,  An-Fang Huang5 and  Li-Chong Su6*
  • 1Department of Evidence-Based Medicine, School of Public Health, Southwest Medical University, 1 Xianglin Road, Luzhou, Sichuan, 646000, P.R. China., China
  • 2Center of Evidence-Based Medicine, School of Public Health, Southwestern Medical University, China
  • 3Laboratory Animal Center, Southwest Medical University, China
  • 4Department of Nutrition and Food Hygiene, School of Public Health, Southwest Medical University, China
  • 5Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, China
  • 6Department of Rheumatology and Immunology, Affiliated Minda Hospital of Hubei Institute for Nationalities, China

Interleukin-36 (IL-36) is a member of the IL-1 superfamily and includes 3 agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal via intracellular functional domains, binding to downstream signalling proteins and inducing inflammatory responses. In this review, we summerized the current knowledge about the biologic role of IL-36 and its correlation with systemic inflammatory diseases. The information collected will help to increase the understanding the potential of IL-36 and may give clues for developing novel therapeutic strategies.

Keywords: IL-36, Autoimmunity, immune cell, Inflammation, cytokine

Received: 23 Apr 2019; Accepted: 11 Oct 2019.

Copyright: © 2019 Yuan, Xu, Fu, Liu, Huang and Su. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Li-Chong Su, Department of Rheumatology and Immunology, Affiliated Minda Hospital of Hubei Institute for Nationalities, Enshi, China, linchong2019@hotmail.com