Impact Factor 4.716 | CiteScore 4.71
More on impact ›

Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.02700

The role of endothelial cells and TNF-receptor superfamily members in lymphoid organ development and maintenance

  • 1Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology and Rheumatology, University of Amsterdam, Netherlands
  • 2Department of Experimental Immunology, Academic Medical Center (AMC), Netherlands
  • 3Department of Molecular Cell Biology and Immunology, VU University Medical Center, Netherlands

Lymph nodes (LNs) are crucial for the orchestration of immune responses. LN reactions depend on interactions between incoming and local immune cells, and stromal cells. To mediate these cellular interactions an organized vascular network within the LN is necessary. In general, the LN vasculature can be divided into two components: blood vessels, which include the specialized high endothelial venules that recruit lymphocytes from the bloodstream, and lymphatic vessels. Signaling via TNF-receptor (R) superfamily (SF) members has been implicated as crucial for the development and function of LNs and the LN vasculature. In recent years the role of cell-specific signaling of TNFRSF members in different endothelial cell (EC) subsets and their roles in development and maintenance of lymphoid organs has been elucidated. Here, we discuss recent insights into EC-specific TNFRSF member signaling and highlight its importance in different EC subsets in lymphoid organogenesis and maintenance during health, and during lymphocyte activation and tertiary lymphoid organ formation in disease.

Keywords: Lymph node (L.N.), endothelial cell, TNFR superfamily, tertiary lymphoid organ, Inflammation, lymph node development, lymph node function, Lymphatic Vessels, High endothelial venule (HEV), NF-kB signaling, LTBR, lymphotoxin β receptor, RANK (TNFRSF11a), TNFR 1

Received: 20 Aug 2019; Accepted: 04 Nov 2019.

Copyright: © 2019 Jeucken, Koning, Mebius and Tas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mx. Kim Jeucken, Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, PO Box 7057, Netherlands, k.c.jeucken@amsterdamumc.nl
MD, PhD. Sander Tas, Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, PO Box 7057, Netherlands, s.w.tas@amsterdamumc.nl