Front. Immunol.Frontiers in ImmunologyFront. Immunol.1664-3224Frontiers Media S.A.10.3389/fimmu.2020.00234ImmunologyCorrectionCorrigendum: Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated MacrophagesOrecchioniMarco1GhoshehYanal1PramodAkula Bala1LeyKlaus12*†1Division of Inflammation Biology, La Jolla Institute for Immunology, La Jolla, CA, United States2Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States
Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland
*Correspondence: Klaus Ley klaus@lji.org
This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
†Present address: Klaus Ley, Division of Inflammation Biology, La Jolla Institute for Immunology, La Jolla, CA, United States
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A Corrigendum on Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages by Orecchioni, M., Ghosheh, Y., Pramod, A. B., and Ley, K. (2019). Front. Immunol. 10:1084. doi: 10.3389/fimmu.2019.01084macrophageinnate immunityM1M2cancer
In the original article, there was a mistake in Figure 3 as published. Three gene names were misspelled in the previous version. In Figure 3A, M1(=LPS+) panel, the correct gene name for EIFE3 is EIF4E3. In Figure 3B, alternatively activated (IL-4) panel, the correct gene name for WRD4 is WDR4. Also in Figure 3B, the correct gene name for POLRR3K is POLR3K. The corrected Figure 3 appears below.
Additionally, in the original article, there was a mistake in the legend for Figure 3 as published. “M1(=LPS+)” was written as “M1(LPS+)”, and “M2(=LPS−)” was written as “M2(LPS−)”. The correct legend for Figure 3 appears below.
In vivo macrophage signatures predict survival in osteosarcoma cancer biopsy transcriptomes. Survival data for human osteosarcoma cancer biopsies (GSE21257) were analyzed for the impact of M1(=LPS+) and classically activated (LPS+IFN-γ) (A) and M2(=LPS−) and alternatively activated (IL-4) (B) gene expression signatures in the tumor biopsy transcriptome. Kaplan–Meier curves were plotted using ProggeneV2, divided by the median of the mean expression of a tumor-specific gene list (in boxes). Hazard ratio (HR, cox proportional hazard analysis) and significance (log rank P-value) are shown. Red, green curves indicate high, low expression of the respective signature genes. The two vertical black lines indicates 3 and 5 years, respectively.
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.