AUTHOR=Liu Shan , Zheng Shu-Cheng , Li Yan-Lian , Li Jun , Liu Hai-Peng 

TITLE=Hemocyte-Mediated Phagocytosis in Crustaceans

JOURNAL=Frontiers in Immunology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00268

DOI=10.3389/fimmu.2020.00268

ISSN=1664-3224

ABSTRACT=Phagocytosis is an ancient, highly conserved process in all multicellular organisms, through which the host can protect itself against invading microorganisms and environmental particles, as well as remove self-apoptotic cells/cell debris in order to maintain tissue homeostasis. In crustacean, phagocytosis by hemocyte has also been well recognized as a crucial defense mechanism for the host against infectious agents such as bacteria and viruses. In this review, we summarized the current knowledge of hemocyte-mediated phagocytosis, in particular focusing on the related receptors for recognition and internalization of pathogens as well as the down-stream signal pathways and intracellular regulators involved in the process of hemocyte phagocytosis. We attempted to gain a deeper understanding of the phagocytic mechanism of different hemocytes and their contribution to the host defense immunity in crustaceans.