TY - JOUR AU - Scheraga, Rachel G. AU - Southern, Brian D. AU - Grove, Lisa M. AU - Olman, Mitchell A. PY - 2020 M3 - Mini Review TI - The Role of TRPV4 in Regulating Innate Immune Cell Function in Lung Inflammation JO - Frontiers in Immunology UR - https://www.frontiersin.org/articles/10.3389/fimmu.2020.01211 VL - 11 SN - 1664-3224 N2 - Ion channels/pumps are essential regulators of innate immune cell function. Macrophages have been increasingly recognized to have phenotypic plasticity and location-specific functions in the lung. Transient receptor potential vanilloid 4 (TRPV4) function in lung injury has been shown to be stimulus- and cell-type specific. In the current review, we discuss the importance of TRPV4 in macrophages and its role in phagocytosis and cytokine secretion in acute lung injury/acute respiratory distress syndrome (ARDS). Furthermore, TRPV4 controls a MAPK molecular switch from predominately c-Jun N-terminal kinase, JNK activation, to that of p38 activation, that mediates phagocytosis and cytokine secretion in a matrix stiffness-dependent manner. Expanding knowledge regarding the downstream mechanisms by which TRPV4 acts to tailor macrophage function in pulmonary inflammatory diseases will allow for formulation of novel therapeutics. ER -