TY - JOUR AU - Cenciarelli, Sabina AU - Calbi, Valeria AU - Barzaghi, Federica AU - Bernardo, Maria Ester AU - Oltolini, Chiara AU - Migliavacca, Maddalena AU - Gallo, Vera AU - Tucci, Francesca AU - Fraschetta, Federico AU - Albertazzi, Elena AU - Fratini, Elena Sophia AU - Consiglieri, Giulia AU - Giannelli, Stefania AU - Dionisio, Francesca AU - Sartirana, Claudia AU - Racca, Sara AU - Camesasca, Chiara AU - Peretto, Giovanni AU - Daverio, Rita AU - Esposito, Antonio AU - De Cobelli, Francesco AU - Silvani, Paolo AU - Rabusin, Marco AU - Cara, Andrea AU - Trabattoni, Daria AU - Dispinseri, Stefania AU - Scarlatti, Gabriella AU - Piemonti, Lorenzo AU - Lampasona, Vito AU - Cicalese, Maria Pia AU - Aiuti, Alessandro AU - Ferrua, Francesca PY - 2020 M3 - Case Report TI - Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report JO - Frontiers in Immunology UR - https://www.frontiersin.org/articles/10.3389/fimmu.2020.603428 VL - 11 SN - 1664-3224 N2 - In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype. ER -