Corrigendum: Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation
- 1MOE Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China
- 2MOE Key Laboratory of Environment and Genes Related to Diseases, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an, China
- 3Roosevelt University College of Pharmacy, Schaumburg, IL, United States
- 4The Affiliated Children’s Hospital of Xi’an Jiaotong University, Xi’an, China
By Jia Z-K, Li H-Y, Liang Y-L, Potempa LA, Ji S-R and Wu Y (2018). Front. Immunol. 9:234. doi: .10.3389/fimmu.2018.00234
Figure 4 mCRP neutralizes the effects of receptor activator of NF-κB ligand (RANKL). Bone marrow-derived macrophages (BMDMs) were treated with 10 ng/mL of M-CSF and 50 ng/ml RANKL in the presence or absence of 100 μg/mL of mCRP. After treatment for 2 days, the expression of TRAP and Cathepsin K were determined by q-PCR (A). After treatment for 6 days, cells were stained for TRAP (B) and counted for the number of osteoclasts (C). Their bone resorption activities were evaluated by toluidine blue staining (D) and the quantification of eroded surface (E). The potent effects of RANKL on BMDMs were absent when treated together with mCRP. Comparable results were also obtained with Raw cells (B–E). *p < 0.05; ***p < 0.001.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Keywords: inflammation, rheumatoid arthritis, osteoclast, receptor activator of NF-κB ligand, C-reactive protein
Citation: Jia Z-K, Li H-Y, Liang Y-L, Potempa LA, Ji S-R and Wu Y (2020) Corrigendum: Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation. Front. Immunol. 11:619847. doi: 10.3389/fimmu.2020.619847
Received: 22 October 2020; Accepted: 30 October 2020;
Published: 24 November 2020.
Edited and reviewed by: Mark Slevin, Manchester Metropolitan University, United Kingdom
Copyright © 2020 Jia, Li, Liang, Potempa, Ji and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.