TY - JOUR AU - Mazzarino, Randall C. PY - 2021 M3 - Perspective TI - Targeting Future Pandemics, a Case for De Novo Purine Synthesis and Basic Research JO - Frontiers in Immunology UR - https://www.frontiersin.org/articles/10.3389/fimmu.2021.694300 VL - 12 SN - 1664-3224 N2 - We are currently experiencing a deadly novel viral pandemic with no efficacious, readily available anti-viral therapies to SARS-CoV-2. Viruses will hijack host cellular machinery, including metabolic processes. Here, I provide theory and evidence for targeting the host de novo purine synthetic pathway for broad spectrum anti-viral drug development as well as the pursuit of basic science to mitigate the risks of future novel viral outbreaks. ER -