Front. Immunol. Frontiers in Immunology Front. Immunol. 1664-3224 Frontiers Media S.A. 10.3389/fimmu.2021.753404 Immunology Correction Corrigendum: The GABAA Receptor Influences Pressure Overload-Induced Heart Failure by Modulating Macrophages in Mice Bu Jin 1 † Huang Shiyuan 2 † Wang Jue 3 Xia Tong 2 Liu Hui 2 You Ya 2 Wang Zhaohui 2 * Liu Kun 4 * 1 Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 2 Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 3 Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 4 Institution of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Edited and reviewed by: Guochang Hu, University of Illinois at Chicago, United States

*Correspondence: Zhaohui Wang, zhaohuiwang@hust.edu.cn; Kun Liu, liukun@hust.edu.cn

†These authors share first authorship

This article was submitted to Inflammation, a section of the journal Frontiers in Immunology

 21 09 2021 2021 12 753404 04 08 2021 24 08 2021 Copyright © 2021 Bu, Huang, Wang, Xia, Liu, You, Wang and Liu 2021 Bu, Huang, Wang, Xia, Liu, You, Wang and Liu

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 A Corrigendum on The GABAA Receptor Influences Pressure Overload-Induced Heart Failure by Modulating Macrophages in Mice by Bu J, Huang S, Wang J, Xia T, Liu H, You Y, Wang Z and Liu K (2021). Front. Immunol. 12:670153. doi: 10.3389/fimmu.2021.670153 GABAA receptor amphiregulin macrophage monocyte pressure-overload hypertrophy

In the original article, there was a mistake in Figure 3A and Supplement 3 as published. In the Figure 3A , the bicuculine group at day 28 post-TAC was inadvertently saved in the improper folders and attached to Sham group at days 14 and 28 post-TAC, so the representative images of Sham group at days 14 and 28 post-TAC were wrong and duplicated. In the Supplement 3 , the representative image of Sham group at day 21 post-TAC was chosen by mistake. The corrected Figure 3A and Supplement 3 appear below.

Activation or blockade of the GABAA receptor selectively increases or reduces the number of Ly6Clow macrophages in the hearts of pressure-overload hypertrophy mice. Macrophage (CD45+F4/80+CD11b+) subpopulations were respectively defined as Ly6Chigh or Ly6Clow macrophages according to Ly-6C expression levels. (A) Representative images of Ly6Chigh and Ly6Clow macrophages at days 7, 14, and 28 post-TAC. The representative images of 1, 3, and 21 days after TAC were shown in supplementary materials. (B) The number of Ly6Clow macrophages or Ly6Chigh macrophages (per mg heart tissue) among the total number of live cells isolated from hearts at the indicated time points after TAC. (C) The number of CD45+CD11b+F4/80+EdU+cell (per mg heart tissue) among the total number of live cells isolated from hearts at the indicated time points after TAC. (D) Representative images of Ki-67+ expression in Ly6Clow macrophages at day 7 post-TAC. (E) The percentage of Ki-67+ expression in Ly6Clow macrophages. Data show the mean ± SEM, by one-way ANOVA with Bonferroni’s multiple comparison test. For topiramate treatment, *P < 0.05 vs. vehicle. For bicuculline treatment, #P < 0.05 vs. vehicle. (n = 3 mice for sham group, n = 6–8 mice for all other groups).

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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 Supplementary Material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2021.753404/full#supplementary-material

Living cells (upper panel) were gated to determine the presence of CD45+Ly6G-CD11b+Ly6Chigh and CD45+Ly6G-CD11b+Ly6Clow monocytes at day 21 post-TAC in the peripheral blood.