TY - JOUR AU - Sherwood, Karen R. AU - Nicholl, David D. M. AU - Fenninger, Franz AU - Wu, Vivian AU - Wong, Paaksum AU - Benedicto, Vince AU - Cina, Davide P. AU - Wang, Meng AU - Pobran, Taylor D. AU - De Marco, Mari L. AU - Márquez, Anna Citlali AU - Jassem, Agatha N. AU - Sekirov, Inna AU - Morshed, Muhammad G. AU - Bardi, Mohammad AU - Sekhon, Mypinder AU - Keown, Paul AU - Kadatz, Matthew AU - Lan, James H. PY - 2021 M3 - Case Report TI - Comprehensive Immune Profiling of a Kidney Transplant Recipient With Peri-Operative SARS-CoV-2 Infection: A Case Report JO - Frontiers in Immunology UR - https://www.frontiersin.org/articles/10.3389/fimmu.2021.753558 VL - 12 SN - 1664-3224 N2 - To date there is limited data on the immune profile and outcomes of solid organ transplant recipients who encounter COVID-19 infection early post-transplant. Here we present a unique case where the kidney recipient’s transplant surgery coincided with a positive SARS-CoV-2 test and the patient subsequently developed symptomatic COVID-19 perioperatively. We performed comprehensive immunological monitoring of cellular, proteomic, and serological changes during the first 4 critical months post-infection. We showed that continuation of basiliximab induction and maintenance of triple immunosuppression did not significantly impair the host’s ability to mount a robust immune response against symptomatic COVID-19 infection diagnosed within the first week post-transplant. ER -