Front. Immunol. Frontiers in Immunology Front. Immunol. 1664-3224 Frontiers Media S.A. 10.3389/fimmu.2021.771779 Immunology Correction Corrigendum: Corticosteroids for Treating Sepsis in Adult Patients: A Systematic Review and Meta-Analysis LiangHuoyan 1 2 † SongHeng 1 2 † ZhaiRuiqing 3 SongGaofei 1 2 LiHongyi 1 2 DingXianfei 1 KanQuancheng 4 * SunTongwen 1 2 * 1General ICU, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou Key Laboratory of Sepsis, Henan Engineering Research Center for Critical Care Medicine, Zhengzhou, China 2Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China 3College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China 4Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Edited and reviewed by: Pietro Ghezzi, Brighton and Sussex Medical School, United Kingdom

*Correspondence: Tongwen Sun, suntongwen@163.com; Quancheng Kan, kanquancheng@126.com

†These authors have contributed equally to this work

This article was submitted to Inflammation, a section of the journal Frontiers in Immunology

 05 11 2021 2021 12 771779 07 09 2021 25 10 2021 Copyright © 2021 Liang, Song, Zhai, Song, Li, Ding, Kan and Sun 2021 Liang, Song, Zhai, Song, Li, Ding, Kan and Sun

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 A Corrigendum on: Corticosteroids for Treating Sepsis in Adult Patients: A Systematic Review and Meta-Analysis By Liang H, Song H, Zhai R, Song G, Li H, Ding X, Kan Q and Sun T (2021). Front. Immunol. 12:709155. doi: 10.3389/fimmu.2021.709155 corticosteroids sepsis mortality systematic review meta-analysis

In the original article, there was a mistake in Figure 2, Supplemental Figures 40-41, 43, 45-46 and Table 2 as published. For Figure 2, we mistakenly adopted the fixed effect model, resulting in the difference between the picture and the actual results. In practice, we need to use the random-effect model to calculate the effect quantity and its 95% CIs, which is the most reasonable. In both the method part and the result part, we describe the calculation using the random effect model. For Supplemental Figures 40-41, 43, 45-46 and Table 2, as we reworked all the figures, we made mistakes in uploading in the revised manuscript. The corrected Figure 2, Supplemental Figures 40-41, 43, 45-46 and Table 2 appear below.

The 28-day mortality of patients with sepsis based on the corticosteroids treatment. The pooled effects in the forest plot were calculated by the M-H method with the random-effects model.

The findings and evidence rank of the included studies in patients with sepsis.

Pooled results No. of Patients (No. of Studies) Relative Effect, RR, or MD (95% CI) Heterogeneity I2,% Absolute effect (95%CI) Evidence rank
Primary outcomes
28 d mortality 10,612 (40) 0.94 (0.87, 1.02) 24 17 fewer per 1000 (from 37 fewer to 6 more) Moderate1
In-hospital mortality 8049 (23) 0.90 (0.82, 0.99) 39 33 fewer per 1000 (from 3 fewer to 60 fewer) Moderate1
ICU mortality 7,152 (17) 0.90 (0.83,0.97) 7 28 fewer per 1000 (from 9 fewer to 48 fewer) High
Secondary outcomes
Long-term mortality 6,254 (9) 0.96 (0.88, 1.05) 54 24 fewer per 1000 (from 48 fewer to 20 more) Low2,3
Shock reversal at 7 d 6,738 (16) 1.16 (1.06,1.27) 72 105 more per 1000 (from 39 more to 178 more) Moderate2
Shock reversal at 28 d 2,526 (12) 1.07 (1.01,1.13) 12 48 more per 1000 (from 7 fewer to 89 more) Moderate2
Gastroduodenal bleeding 5,128 (24) 1.07 (0.85,1.36) 0 3 more per 1000 (from 7 fewer to 17 more) High
Superinfection 5,375 (24) 1.06 (0.92, 1.22) 13% 10 more per 1000 (from 13 fewer to 36 more) Moderate2
Hypernatremia 4,569 (3) 1.51 (1.10,2.07) 0 12 more per 1000 (from 2 more to 24 more) Moderate2
Hyperglycemia 8,787 (20) 1.19 (1.10,1.29) 49% 49 more per 1000 (from 24 more to 76 more) High
Vasopressor-free days 1,316 (2) 1.93 (0.76, 3.09) 0 1.93 more per 1000 (from 0.76 more to 3.09 more) Moderate2
Ventilation-free days 1,812 (4) 1.46 (0.27, 2.65) 21 1.46 more per 1000 (from 0.27 more to 2.65 more) Moderate2
Length of stay in hospital 8,383 (19) -1.38(-2.28, -0.49) 5 1.38 fewer per 1000 (from 2.28fewer to 0.49 fewer) High
Length of stay in ICU 8,166 (22) -0.89 (-1.80, 0.03) 47 0.89 fewer per 1000 (from 1.8 fewer to 0.03 more) High
Time to resolution of shock 4,091 (5) -1.35(-1.79, -0.92) 68 1.35 fewer per 1000 (from 1.79 fewer to 0.92 fewer) Low2,3
SOFA score at day 7 3,076 (13) -0.90 (-1.72, -0.09) 93 0.9 fewer per 1000 (from 1.72 fewer to 0.08 fewer) Low2,3

RR, risk ratio; MD, mean difference; ICU, intensive care unit.

1Inconsistencies. 2Imprecisions. 3Risk of bias.

In the original article, there was an error. As the outcomes for Hypernatremia, Hyperglycemia and SOFA at day 7 were revised several times, and the pooled effects were not changed, but the up or low 95% CI had a little change. When we modified, we ignored the modifications in the two places.

A correction has been made to RESULTS, Secondary Outcomes of RESULTS, Paragraph 1 :

“Supplementary Figures 10–22 present the assessment of the secondary outcomes. Corticosteroids achieved a small reduction in length of stay in hospital (MD, −1.38; 95% CI, −2.28 to −0.49; I2 = 5%; evidence rank, high), SOFA scores at day 7 (MD, −0.90; 95% CI, −1.72 to −0.09; I2 = 93%; evidence rank, low), and time to resolution of shock (MD, −1.35; 95% CI, −1.79 to −0.92; I2 = 68%; evidence rank, low) for patients with sepsis. Conversely, corticosteroids resulted in higher risk of hypernatremia (RR, 1.51; 95% CI, 1.10–2.07; I2 = 0%; evidence rank, moderate) and hyperglycemia (RR, 1.19; 95% CI, 1.10–1.29; I2 = 49%; evidence rank, high).”

The authors apologize for these errors and state that they do not change the scientific conclusions of the article in any way. The original article has been updated.

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 Supplementary Material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2021.771779/full#supplementary-material