Sec. Comparative Immunology
Corrigendum: Type I Interferon Regulates the Survival and Functionality of B Cells in Rainbow Trout
- 1Animal Health Research Center (CISA-INIA), Madrid, Spain
- 2Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
By Benedicenti O, Wang T, Morel E, Secombes CJ, Soleto I, Díaz-Rosales P and Tafalla C (2020). Front. Immunol. 11:1494. doi: 10.3389/fimmu.2020.01494
Figure 1 Survival of blood IgM+IgD+ B cells in response to type I and type II IFNs. PBLs were stimulated with 50 ng/ml rIFNa, 20 ng/ml rIFNg or media alone (control) and cultured at 20°C for 72 h. Leukocytes were then labeled with specific monoclonal antibodies against trout IgM and IgD and analyzed by flow cytometry. Cells were gated on the basis of their FSC and SSC and percentages of IgM+IgD+ cells determined on singlet and live (DAPI negative) cells. Representative dot plots from one individual fish are shown (A) along with mean percentages and total number of cells detected for IgM+IgD+ B cells (B) and IgM−IgD− cells (C) (mean + SEM; n = 9). In an independent experiment, B cells were sorted from blood leukocytes using a biotinyilated Fab fragment of anti-IgM 1.14 and then incubated with the rIFNs as described above. After 72 h, the percentage of live IgM+IgD+ B cells and the total number of live IgM+IgD+ B cells determined by flow cytometry as described in the Materials and Methods section (mean + SEM; n = 7) (D). Asterisks denote significant differences between samples treated with rIFNs and control samples (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001).
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Keywords: teleost fish, B cells, interferon (IFN), IgM, phagocytosis
Citation: Benedicenti O, Wang T, Morel E, Secombes CJ, Soleto I, Díaz-Rosales P and Tafalla C (2021) Corrigendum: Type I Interferon Regulates the Survival and Functionality of B Cells in Rainbow Trout. Front. Immunol. 12:778085. doi: 10.3389/fimmu.2021.778085
Received: 16 September 2021; Accepted: 29 September 2021;
Published: 18 October 2021.
Edited and reviewed by:Lluis Tort, Universitat Autònoma de Barcelona, Spain
Copyright © 2021 Benedicenti, Wang, Morel, Secombes, Soleto, Díaz-Rosales and Tafalla. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Carolina Tafalla, firstname.lastname@example.org