%A Andriamanantena,Zo
%A Randrianarisaona,Fanirisoa
%A Rakotondrainipiana,Maheninasy
%A Andriantsalama,Prisca
%A Randriamparany,Ravaka
%A Randremanana,Rindra
%A Randrianirina,Frédérique
%A Novault,Sophie
%A Duffy,Darragh
%A Huetz,François
%A Hasan,Milena
%A Schoenhals,Matthieu
%A Sansonetti,Philippe J.
%A Vonaesch,Pascale
%A Vigan-Womas,Inès
%A ,Afribiota Investigators
%A Barbot-Trystram,Laurence
%A Barouki,Robert
%A Bastaraud,Alexandra
%A Collard,Jean-Marc
%A Doria,Maria
%A Duffy,Darragh
%A Djorie,Serge Ghislain
%A Giles-Vernick,Tamara
%A Gondje,Bolmbaye Privat
%A Gody,Jean-Chrysostome
%A Hasan,Milena
%A Héraud,Jean-Michel
%A Hunald,Francis Allan
%A Kapel,Nathalie
%A Lombart,Jean-Pierre
%A Manirakiza,Alexandre
%A Nigatoloum,Synthia Nazita
%A Parfrey,Laura Wegener
%A Raharimalala,Lisette
%A Rakotondrainipiana,Maheninasy
%A Randremanana,Rindra Vatosoa
%A Randriamizao,Harifetra Mamy Richard
%A Randrianirina,Frédérique
%A Robinson,Annick Lalaina
%A Rubbo,Pierre-Alain
%A Sansonetti,Philippe
%A Schaeffer,Laura
%A Gouandjika-Vassilache,Ionela
%A Vonaesch,Pascale
%A Vondo,Sonia Sandrine
%A Vigan-Womas,Inès
%D 2022
%J Frontiers in Immunology
%C
%F
%G English
%K stunting,environmental enteric dysfunction,Flow Cytometry,Monocytes,regulatory T cells,Madagascar,Systemic immune cells
%Q
%R 10.3389/fimmu.2022.864084
%W
%L
%M
%P
%7
%8 2022-June-02
%9 Original Research
%+ Inès Vigan-Womas,Immunology of Infectious Diseases Unit, Institut Pasteur de Madagascar,Madagascar,ines.vigan-womas@pasteur.fr
%#
%! Systemic immune population changes during stunting
%*
%<
%T Changes in Systemic Regulatory T Cells, Effector T Cells, and Monocyte Populations Associated With Early-Life Stunting
%U https://www.frontiersin.org/articles/10.3389/fimmu.2022.864084
%V 13
%0 JOURNAL ARTICLE
%@ 1664-3224
%X Stunting and environmental enteric dysfunction (EED) may be responsible for altered gut and systemic immune responses. However, their impact on circulating immune cell populations remains poorly characterized during early life. A detailed flow cytometry analysis of major systemic immune cell populations in 53 stunted and 52 non-stunted (2 to 5 years old) children living in Antananarivo (Madagascar) was performed. Compared to age-matched non-stunted controls, stunted children aged 2-3 years old had a significantly lower relative proportion of classical monocytes. No significant associations were found between stunting and the percentages of effector T helper cell populations (Th1, Th2, Th17, Th1Th17, and cTfh). However, we found that HLA-DR expression (MFI) on all memory CD4+ or CD8+ T cell subsets was significantly lower in stunted children compared to non-stunted controls. Interestingly, in stunted children compared to the same age-matched non-stunted controls, we observed statistically significant age-specific differences in regulatory T cells (Treg) subsets. Indeed, in 2- to 3-year-old stunted children, a significantly higher percentage of memory Treg, whilst a significantly lower percentage of naive Treg, was found. Our results revealed that both innate and adaptive systemic cell percentages, as well as activation status, were impacted in an age-related manner during stunting. Our study provides valuable insights into the understanding of systemic immune system changes in stunted children.