Gut microbes in central nervous system development and related disorders
Jiawei Geng- 1The First People’s Hospital of Yunnan Province, China
- 2Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), China
The association between gut microbiota and central nervous system (CNS) development has garnered significant research attention in recent years. Evidence suggests bidirectional communication between the CNS and gut microbiota through the brain-gut axis. As a long and complex process, CNS development is highly susceptible to both endogenous and exogenous factors. The gut microbiota impacts the CNS by regulating neurogenesis, myelination, glial cell function, synaptic pruning, and bloodbrain barrier permeability, with implication in various CNS disorders. This review outlines the relationship between gut microbiota and stages of CNS development (prenatal and postnatal), emphasizing the integral role of gut microbes. Furthermore, the review explores the implications of gut microbiota in neurodevelopmental disorders, such as autism spectrum disorder, Rett syndrome, and Angelman syndrome, offering insights into early detection, prompt intervention, and innovative treatments.
Keywords: CNS development, Gut microbes, Autism Spectrum Disorder, Rett Syndrome, Angelman Syndrome
Received: 04 Sep 2023;
Accepted: 22 Dec 2023.
Copyright: © 2023 Gan, Chen, Zhong, Liu, Geng, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: MD. Jiawei Geng, The First People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China